Daniel Tso, PhD

CLINICAL TRIALS

协会/会员

RESEARCH ABSTRACT

视觉知觉的皮质机制

The long-term goal of our work is to arrive at a deeper understanding of the neural mechanisms underlying visual perception. Although we have chosen to focus on the processing in the visual system, 神经元组织的机制, interaction and connectivity that we are studying hold broad implications for our understanding of brain in both normal and diseased states. One important theme concerns the classes of neuronal interactions between different cortical areas, the study of which should lead to an understanding of why and how the brain is divided up into so many areas, many of which seem to have functions that to some degree overlap with those of other areas. 我们正在研究不同的视觉区域是如何相互作用的, 这些区域之间传递什么样的信息, 为什么需要多个皮质区域而不是一个, and how in general do multiple cortical areas cooperate with each other. A second theme in our research addresses the types of functional organization in the neocortex, 每个功能域是如何分离的, 多么不同的组织模式啊, 以及功能域如何在给定的皮质区域内相互作用. These studies have important implications for our understanding of how the cortex represents multiple processing dimensions in the same cortical area.

我们的研究使用解剖学, 生理和功能成像技术, have revealed separate pathways for distinct aspects of visual processing. Optical imaging results show a patchwork of cortical modules or cortical maps dedicated to visual features, such as form, color and depth. Multi-electrode single-cell electrophysiology has shown both the properties of individual neurons, and how ensembles of neurons cooperate to ultimately yield visual perception, 物体识别和视觉引导行为.

Our research should not only lead to a better understanding of the nature of brain function and architecture, but will provide insights into disease states that involve neuronal connectivity, 比如阿尔茨海默氏症和癫痫, 还有中枢视觉障碍.

无创视网膜成像

We have adapted the technique of intrinsic signal optical imaging of neural activity to the noninvasive functional imaging of retina, and demonstrated the feasibility and potential of this new method for the functional assessment of the retina. 就像对新皮层的研究一样, this retinal functional imaging technique measures functionally correlated intrinsic optical signals in the retina such as total hemoglobin concentration and deoxy/oxy-hemoglobin exchange. 通过改良的眼底摄像头, this technique enables us to visualize the patterns of activity in the intact retina while presenting visual stimuli. The most anticipated applications of this technology are those in ophthalmology, in the study, 视网膜疾病的诊断与治疗, 以及视网膜功能的基础研究.

选择引用

-Ts'o, DY, Frostig RD, like, EE, grinwald, A.  Functional organization of primate visual cortex revealed by high resolution optical imaging of intrinsic signals.  科学(1990)240:417-420.
-Roe, AW和Ts'o, DY.  Visual topography in primate V2: multiple representation across functional stripes. J. Neurosci. (1995) 15:3689-3715.
-Ghose, GM和Ts'o, DY. 灵长类区域V4的表单处理模块. J. Neurophys. (1997) 77:2191-2196.
-Abramoff, M, Kwon, Y, Tso, DY, Soliz, P, Zimmerman, B. Pokorny, J, Kardon, R. (2006) Visual Stimulus-Induced Changes in Human Near-Infrared Fundus Reflectance. 生物学报，2006,47:715-721.
-Yang, JN, Szeverenyi, NM, Tso, DY. Neural Resources Associated with Perceptual Judgement across Sensory Modalities. 大脑皮质，(2008)18:38-45.
-陆海东，陈刚，曹德华，罗亚华. A rapid topographic mapping and eye alignment method using optical imaging in Macaque visual cortex (2009) Neuroimage 44(3):636-46.
-Tso D, Zarella M, Burkitt G. (2009) Hypercolumn? J. Physiol. 587:2791-2805.
-Schallek, JB, Li, H, Kardon, R, Kwon, Y, Abramoff, Soliz, P, Tso, DY. Stimulus-Evoked Intrinsic Optical Signals in the Retina: Spatial and Temporal Characteristics. (2009) Invest. Ophthal. Vis. Sci. 50:4865-4872.
-Schallek, JB, Kardon, R, Kwon, Y, Abramoff, Soliz, P, Tso, DY. Stimulus-Evoked Intrinsic Optical Signals in the Retina: Pharmacological Dissection Reveals Outer Retinal Origins (2009) Invest. Ophthal. Vis. Sci. 50:4873-4880.
-Tso, DY, Schallek, JB, Kwon, Y, Kardon, R, Abramoff, Soliz, P. (2009) Non-Invasive Functional Imaging of the Retina Reveals Outer Retinal and Hemodynamic Intrinsic Optical Signal Origins, Jap. J. Ophthal. 53: 334-344.
-Schallek, JB, Tso, DY. Blood contrast agents enhance intrinsic signals in the retina: Evidence for an underlying blood volume component. Invest. Ophthal. Vis. Sci. 52: 1325-1335 (2011).
-Schallek. JB, McLellan, G, Viswanathan, S和Ts'o, DY.  Retinal Intrinsic Optical Signals in a Cat Model of Primary Congenital Glaucoma, Invest. Ophthal. Vis. Sci. 53: 1971-81 (2012).

Reviews

-Tso, DY和Roe, AW. Functional compartments in visual cortex: segregation and interaction. The Cognitive Neurosciences, Gazzaniga, MS (ed), MIT Press (1994), Cambridge, pp. 325-337.
-Tso, DY和Roe, AW. The functional architecture of area V2 in the macaque monkey: Physiology, 地形与连通性. 《推荐最近最火的赌博软件》，卡斯，J. and Rockland, K. (编辑)，全会出版社(1998).